Irvine, California August 4, 2010 – New Earth BioMed, a new 501(c)3 nonprofit corporation, has launched a long-term drug discovery program to identify mixtures of nontoxic plant compounds useful in treating cancer. An estimated 77 percent of approved cancer and anti-infective drugs in the United States are either natural products or are derived from them. [...]
New Earth BioMed launches natural-product-based cancer drug discovery program
July 28, 2010 – 6:22 pm
Types of Chemotherapy Drugs
July 28, 2010 – 6:21 pm
The current arsenal of chemotherapy drugs consists primarily of cytotoxic agents, targeted therapy drugs, sex hormones, and immunostimulants. Each are discussed briefly below. The actions of some cytotoxic drugs are cell-cycle specific, and so we start with a quick review of cell division. Most cells in adults do not divide frequently. Cell division is only [...]
Lasers and CARS
July 28, 2010 – 6:20 pm
A core technology in the New Earth BioMed mixture discovery program is a laser-based analytical tool based on choerent anti-Stokes Raman scattering (CARS) [1,2,3]. This article describes some technical concepts behind Raman scattering and CARS. Scattering is a process by which molecules cause an incident photon to change direction. Scattering can be elastic, where the [...]
Roadmap Chapter 1
July 28, 2010 – 6:09 pm
New Earth BioMed (NEBM) is a 501(c)3 nonprofit corporation dedicated to the discovery of useful therapeutic agents from natural products. Contingent on adequate funding, this roadmap describes an ambitious long-term drug discovery program focused on identifying personalized mixtures of therapeutic agents that are effective against cancer. Mixtures will consist primarily or solely of natural products, will contain numerous components, and will be designed for oral administration. The basis for this program is rapidly mounting evidence that suggests:
Roadmap Chapter 2
July 28, 2010 – 6:08 pm
This chapter provides a very brief review of protein biology and a short history of cancer drug discovery. The background information in this chapter and the next provides a basis for understanding the strategy that NEBM is adopting in its mixture discovery program.
Roadmap Chapter 3
July 28, 2010 – 6:07 pm
This chapter further discusses background material that will help describe the NEBM mixture discovery program. It provides a brief overview of the structure of biological networks, discusses how drugs can interact to affect the network, and discusses some molecular targets other than classic protein targets.
Roadmap Chapter 4
July 28, 2010 – 6:06 pm
This chapter outlines New Earth BioMed’s mixture discovery program, the core of which is a medium-throughput screening program that will assess thousands of mixtures. The discovery program was initiated in the spring of 2010 and is, necessarily, a work-in-progress. Full implementation will require an expanded staff and years of effort. Over time, modifications and refinements to the discovery program are certain to be made. Nevertheless, our intention is to provide a sketch of the program in order to inform our supporters of the general direction we are headed.
Dr. Boik in Aix-en Provence, France, 2009. Part 1
July 28, 2010 – 6:05 pm
This series of videos features John Boik, PhD speaking at Congrès “UN AUTRE REGARD SUR LE CANCER”, (A New Look at Cancer) in Aix-en Provence, France, April 17 and 18, 2009. Roughly 1,500 patients, physicians, and supporters were present in the auditorium. For more information, see www.tribucancer.org. The talk by Dr. Boik is split into [...]
Dr. Boik in Aix-en Provence, France, 2009. Part 2
July 28, 2010 – 6:04 pm
This series of videos features John Boik, PhD speaking at Congrès “UN AUTRE REGARD SUR LE CANCER”, (A New Look at Cancer) in Aix-en Provence, France, April 17 and 18, 2009. Roughly 1,500 patients, physicians, and supporters were present in the auditorium. For more information, see www.tribucancer.org. The talk by Dr. Boik is split into [...]
Dr. Boik in Aix-en Provence, France, 2009. Part 3
July 28, 2010 – 6:03 pm
This series of videos features John Boik, PhD speaking at Congrès “UN AUTRE REGARD SUR LE CANCER”, (A New Look at Cancer) in Aix-en Provence, France, April 17 and 18, 2009. Roughly 1,500 patients, physicians, and supporters were present in the auditorium. For more information, see www.tribucancer.org. The talk by Dr. Boik is split into [...]